Proliferative Lesions of the Glandular Stomach and Liver in F344 Rats Fed Diets Containing Aroclor 1254

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Proliferative lesions of the glandular stomach and liver in F344 rats fed diets containing Aroclor 1254.

Aroclor 1254 was fed to groups of 24 male and 24 female F344 rats, from 7 weeks of age, at dietary concentrations of 25, 50 and 100 ppm for up to 105 weeks. There was a dose- related depression of body weight gain for both sexes and decrease in survival for male rats. Histologically, an increased incidence of gastric intestinal metaplasia and adenocarcinoma was found in both sexes. Hepatocellul...

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Aroclor 1254-induced intestinal metaplasia and adenocarcinoma in the glandular stomach of F344 rats.

Ingestion of diets containing Aroclor 1254, a mixture of polychlorinated biphenyls, for 2 years led to a dose-related increase in the incidence of focal lesions in the glandular stomachs of male and female F344 rats. The incidence of stomach lesions was 6% in control specimens and in specimens from rats fed a diet containing 25, 50, or 100 ppm Aroclor 1254, the incidences of stomach lesions wer...

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Aroclor 1254-induced intestinal Metaplasia and Adenocarcinoma in the Glandular Stomach of F344 Rats1

Ingestion of diets containing Aroclor 1254, a mixture of polychlorinated biphenyls, for 2 years led to a dose-related increase in the incidence of focal lesions in the glandular stomachs of male and female F344 rats. The incidence of stomach lesions was 6% in control specimens and in speci mens from rats fed a diet containing 25, 50, or 100 ppm Aroclor 1254, the incidences of stomach lesions we...

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Proliferative lesions in the male reproductive system of F344 rats and B6C3F1 mice: incidence and classification.

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ژورنال

عنوان ژورنال: Environmental Health Perspectives

سال: 1985

ISSN: 0091-6765

DOI: 10.2307/3429948